Cell and Animal Models in Aging and Dementia Research by H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D.

By H. Oberpichler-Schwenk (auth.), Prof. Dr. S. Hoyer, Dr. D. Müller, Dr. K. Plaschke (eds.)

Although age has been famous as a danger issue for late-onset dementia of Alzheimer kind, its etiology is unknown as but. a number of age-related metabolic abnormalities may perhaps therefore turn into very important for the pathogenesis of the late-onset shape. reports on the cellular/molecular point in mind tissue are attainable submit mortem, yet lack details at the starting of the illness. during this complement, varied techniques are handled the way to set off structural and/or metabolic abnormalities in proper mobilephone cultures, in mind slices and in experimental animals, and the way behavioral adjustments parallel the metabolic variations.

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J Neurosci 13: 1676-1686 Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) In vitro aging of ~-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563: 311-314 Pryor WA (1987) Modern biological theories of aging. Raven Press, New York, p 89 Quon D, Catalano R, Cordell B (1990) Fibroblast growth factor induces beta amyloid precursor mRNA in glial but not neuronal cultured cells. Biochem Biophys Res Commun 167: 96-102 44 V. L. Smith-Swintosky and M. P. Mattson Richardson JS, Subbarao KV, Ang LC (1990) Biochemical indices of peroxidation in Alzheimer's and control brains.

Elliott, K. Kumar, I. Lieberburg, R. Mark, E. K. Michaelis, J. A. O'Keefe, L. C. Pettigrew, R. E. Rydel and R. M. Sapolsky, for their invaluable contributions to the research. We also appreciate the excellent technical assistance of M. M. Barger, S. Bose, Y. Goodman, J. J. Joseph, S. E. Loughran, J. Mattson, J. Oeltgen and Y. Zhang. M. S. from the Kentucky Research Foundation. References Abe K, Tanzi RE, Kogure K (1991) Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex.

E. Rydel and R. M. Sapolsky, for their invaluable contributions to the research. We also appreciate the excellent technical assistance of M. M. Barger, S. Bose, Y. Goodman, J. J. Joseph, S. E. Loughran, J. Mattson, J. Oeltgen and Y. Zhang. M. S. from the Kentucky Research Foundation. References Abe K, Tanzi RE, Kogure K (1991) Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett 125: 172-174 Andorn AC, Britton RS, Bacon RR (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer's brain.

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