Interferons: Mechanisms of Action and Role in Cancer Therapy by Derek Crowther (auth.), Professor Derek Crowther (eds.)

By Derek Crowther (auth.), Professor Derek Crowther (eds.)

A good deal of latest details has been received in the past 4 years, and this monograph presents a transparent and good reviewed replace on biochemical mechanisms and the result of vital new medical reviews utilizing the interferons. studies comprise what's shortly identified concerning the biosynthesis, physiological position and mechanisms of motion of the interferons (alpha, beta, gamma). New biochemical details on interferon-receptor interactions and signalling pathways is supplied. The pharmacokinetic concerns in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and different stable tumors are reviewed with particular emphasis on reviews of adjuvant chemotherapy in malignancies of the immune system.

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Extra info for Interferons: Mechanisms of Action and Role in Cancer Therapy

Sample text

The rationale for the combination was based on the results of experiments in murine L 1210 leukaemia [24] and AKR lymphoma [25], which suggested synergy. Later studies in nude mice bearing human breast cancer xenografts once more demonstrated synergy between interferon and the drugs adriamycin and cyclophosphamide [26]. albeit in a different disease, a study was carned out at St. Bartholomew's Hospital, London, combining chlorambucil given at conventional dose, with interferon given at low dose, thrice weekly, subcutaneously, in patients with low-grade lymphoma in whom conventional treatment had failed [27].

3). There was no significant difference in survival between Groups Band C. The 5- and 10-year survival rates from diagnosis in our interferontreated patients were 80%. In a study by Moertel and colleagues from the Mayo Clinic [25] who used higher doses of alpha-IFN 2a (Roferon), median 24 x 10 MU/m 2/day subcutaneously, similar objective response rates were obtained in 27 patients with metastatic carcinoid tumours. Thirty-nine percent of the patients showed biochemical responses and 20% a significant reduction in tumour size.

Adv Cancer Res 1986 (46):1-256 8 Ratain MJ, Vardiman JW and Golomb HM: The role of interferon in the treatment of hairy cell leukemia. Semin Oncol1986 (13):21-28 9 Talpaz M, McCredie KB, Mavligit GM and Gutterman JU: Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia. Blood 1983 (62):689-692 10 Aapro MS, Alberts DS and Salmon SE: Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in cionogenic assay.

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